From time immemorial plants have been used as a source for health care by human society. In this preclinical study, three polyherbal appetizers formulation churna were prepared using medicinal plants such as Zingiber officinale, Carum carvi, Terminalia chebula, Piper nigrum, Plectranthus Amboinicus, Eugenia Caryophyllus, Foeniculum vulgare, Coriandrum sativum, Mentha piperita. The present study is undertaken to investigate the effects of appetizers on food consumption, weight gain, and leptin levels in Wistar rats. The polyherbal appetizer churna were prepared in lab scale and administered to groups of rats. The Fasting leptin levels of the rats ranged from 1.07 to 1.11 ng/ml, while weights were in the range of 92.2 to 122.4 gm. Decreased (18.01, 13.63, and 11.81%) leptin levels following the consumption of three appetizers indicated their appetizing effect. Weight gain after 15 days was 4.37% in the control group whereas 55.17, 43.20 and 32.77% in rats fed with three different polyherbal appetizer churna, respectively. \nKeywords: Appetizer, Food Consumption, Leptin, Churna
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